COX inhibitors directly alter gene expression: role in cancer prevention?
نویسندگان
چکیده
منابع مشابه
The Role of Nutrition in Cancer Prevention
سرطان در نتیجه ناهنجاری های متفاوتی ایجاد می شود و در فرآیند سلولی زمانی که تبدیل و تجدید سلول ها از کنترل خارج می شود شکل می گیرد. به طور کلی برای سرطان مراحل فاز ابتدائی، آغازین و درصد در نظر گرفته شده است. سرطان سالیانه باعث مرگ و میر زیادی می گردد.
متن کاملGene modulation by Cox-1 and Cox-2 specific inhibitors in human colorectal carcinoma cancer cells.
Cox-1 and Cox-2 specific inhibitors exert chemo-preventative activity. However, the exact mechanisms for this activity remain unclear. Increasing evidence suggests that non-steroidal anti-inflammatory drugs regulate gene expression, which may be responsible, in part, for this activity. In this study, human colorectal carcinoma HCT-116 cells were treated with the Cox-1 specific inhibitor SC-560 ...
متن کاملCompare the effect of ginger extract and aspirin on COX-2 gene expression in colon cancer cell line HT-29
Background and aim: Colon cancer is the third most prevalent cancer in Iran. Prolonged colon inflammation is an important factor, in the development of colon cancer. Ginger has anti-inflammatory properties due to its content of [6]-gingerol and hence can play a role in the prevention of colon cancer. In this research the effects of ginger extract on reducing expression of the C...
متن کاملCompare the effect of ginger extract and aspirin on COX-2 gene expression in colon cancer cell line HT-29
Background and aim: Colon cancer is the third most prevalent cancer in Iran. Prolonged colon inflammation is an important factor, in the development of colon cancer. Ginger has anti-inflammatory properties due to its content of [6]-gingerol and hence can play a role in the prevention of colon cancer. In this research the effects of ginger extract on reducing expression of the C...
متن کاملCOX-2 inhibition in clinical cancer prevention.
Colorectal cancer is an excellent model for studying cancer prevention by means of secondary (e.g., polypectomy to remove a precursor adenoma) and primary (chemoprevention) strategies. Evidence has shown that regular users of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) have a reduction in risk of colorectal cancer. A possible mechanism of this benefit is decreased prostaglan...
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ژورنال
عنوان ژورنال: Cancer and Metastasis Reviews
سال: 2011
ISSN: 0167-7659,1573-7233
DOI: 10.1007/s10555-011-9301-4